From Maciej.Lisicki at fuw.edu.pl Sun Oct 6 21:46:29 2024 From: Maciej.Lisicki at fuw.edu.pl (Maciej Lisicki) Date: Sun, 6 Oct 2024 21:46:29 +0200 Subject: [Soft-matter] Soft Matter & Complex Systems Seminar on 11 Oct 2024 Message-ID: <9681D89B-6F69-4DEE-B634-954329F19661@fuw.edu.pl> Dear Soft Matter & Complex Systems Colleagues and Friends, On Friday 4 October 2024 at 9:30 AM at the UW Faculty of Physics (Pasteura 5, Warsaw; room 1.40) we are hosting a seminar during which Andrej Vilfan (J. Stefan Institute, Ljubljana, Slovenia) will give a talk Minimum dissipation theorems for microswimmers Abstract Microswimmers are natural or artificial self-propelled microscaleobjects moving through a fluid at low Reynolds numbers. The entropyproduction of microswimmers, related to their dissipated power,consists of two contributions. The external dissipation takes place inthe viscous fluid surrounding the microswimmer. Internal dissipationtakes place in the propulsive layer on the swimmer's surface. We haveshown that a lower bound on the external dissipation can be derivedwith the knowledge of drag coefficients of two bodies of the sameshape, one with a no-slip and one with a perfect slip boundarycondition [1]. This approach can be generalized to take into accountthe internal dissipation, which is often the dominant contribution. Bycombining the Helmholtz minimum dissipation theorem and the principleof linear superposition, we solve the combined minimum dissipationproblem for different classes of swimmers including surface-drivenviscous droplets, Marangoni surfers, etc. [2,3]. We show that theminimum entropy production in suspensions of active microswimmersdiffers fundamentally from particles driven by external forces. [1] B. Nasouri, A. Vilfan and R. Golestanian, Phys. Rev. Lett., 126,034503 (2021) [2] A. Daddi-Moussa-Ider, R. Golestanian and A. Vilfan, Nat. Commun.14, 6060 (2023) [3] A. Daddi-Moussa-Ider, R. Golestanian and A. Vilfan, J. Fluid Mech.986, A32 (2024) We warmly welcome everyone to attend the talk and the Soft Matter Coffee Break after the seminar, held in room 2.63 (2nd floor). Maria Ekiel-Je?ewska Maciej Lisicki Piotr Szymczak Panagiotis Theodorakis Marek Trippenbach -------------- next part -------------- An HTML attachment was scrubbed... URL: From Maciej.Lisicki at fuw.edu.pl Sun Oct 6 22:57:48 2024 From: Maciej.Lisicki at fuw.edu.pl (Maciej Lisicki) Date: Sun, 6 Oct 2024 22:57:48 +0200 Subject: [Soft-matter] Soft Matter & Complex Systems Seminar on 11 Oct 2024 Message-ID: <7A3019FC-8F30-48EA-B6EB-D163A0E9FD21@fuw.edu.pl> ?Dear all, Apologies for the typographic error - the seminar of A. Vilfan is on Friday 11 October. > On 6 Oct 2024, at 21:46, Maciej Lisicki wrote: > ? > Dear Soft Matter & Complex Systems Colleagues and Friends, > > On Friday 4 October 2024 at 9:30 AM at the UW Faculty of Physics (Pasteura 5, Warsaw; room 1.40) we are hosting a seminar during which > > Andrej Vilfan (J. Stefan Institute, Ljubljana, Slovenia) > > will give a talk > Minimum dissipation theorems for microswimmers > > Abstract > > Microswimmers are natural or artificial self-propelled microscaleobjects moving through a fluid at low Reynolds numbers. The entropyproduction of microswimmers, related to their dissipated power,consists of two contributions. The external dissipation takes place inthe viscous fluid surrounding the microswimmer. Internal dissipationtakes place in the propulsive layer on the swimmer's surface. We haveshown that a lower bound on the external dissipation can be derivedwith the knowledge of drag coefficients of two bodies of the sameshape, one with a no-slip and one with a perfect slip boundarycondition [1]. This approach can be generalized to take into accountthe internal dissipation, which is often the dominant contribution. Bycombining the Helmholtz minimum dissipation theorem and the principleof linear superposition, we solve the combined minimum dissipationproblem for different classes of swimmers including surface-drivenviscous droplets, Marangoni surfers, etc. [2,3]. We show that theminimum entropy production in suspensions of active microswimmersdiffers fundamentally from particles driven by external forces. > > [1] B. Nasouri, A. Vilfan and R. Golestanian, Phys. Rev. Lett., 126,034503 (2021) > [2] A. Daddi-Moussa-Ider, R. Golestanian and A. Vilfan, Nat. Commun.14, 6060 (2023) > [3] A. Daddi-Moussa-Ider, R. Golestanian and A. Vilfan, J. Fluid Mech.986, A32 (2024) > > We warmly welcome everyone to attend the talk and the Soft Matter Coffee Break after the seminar, held in room 2.63 (2nd floor). > > Maria Ekiel-Je?ewska > Maciej Lisicki > Piotr Szymczak > Panagiotis Theodorakis > Marek Trippenbach -------------- next part -------------- An HTML attachment was scrubbed... URL: From Maciej.Lisicki at fuw.edu.pl Tue Oct 15 08:51:57 2024 From: Maciej.Lisicki at fuw.edu.pl (Maciej Lisicki) Date: Tue, 15 Oct 2024 08:51:57 +0200 Subject: [Soft-matter] Soft Matter & Complex Systems Seminar on 18 Oct 2024 Message-ID: <4DD854E3-E959-4F94-8E4F-2824F597062B@fuw.edu.pl> Dear Soft Matter & Complex Systems Colleagues and Friends, On Friday 18 October 2024 at 9:30 AM at the UW Faculty of Physics (Pasteura 5, Warsaw; room 1.40) we are hosting a seminar during which Krzysztof Kuczera (Department of Chemistry and2Department of Molecular Biosciences, The University of Kansas, Lawrence, KS, USA) will give a talk Discovery and Characterization of Blood-Brain Barrier Modulating Peptides based on E-cadherin Abstract The delivery of pharmaceutical agents to the central nervous system is hindered by the Blood-Brain Barrier (BBB), a network of inter-cellular interactions of the epithelium. Here, we present a search for novel peptides able to modulate the BBB, focusing on the E-cadherin protein, which is involved in the formation of these intercellular junctions. Previously, two classes of peptides, HAV and ADT, were known to modulate BBB permeability in vitro and in vivo. Here we use computational methods to perform a systematic search for novel peptides which can effectively interfere with E-cadherin interactions. Employing protein-protein and peptide-protein docking methods with varied levels of flexibility, we propose 115 different peptides with a high binding affinity for E-cadherin as candidates for disrupting the BBB. Several strongest binders have been selected for experimental validation and further sequence optimization. Additionally, conformations of selected peptides in aqueous solution were explored with molecular dynamics simulations, showing a general preference for extended structures and fast conformational equilibria, on the 10-100 ns time scales. Thus, this work presents a systematic computational approach for generating novel peptides with high potential for disrupting the BBB and enabling drug delivery to the central nervous system. A graphical abstract is attached. We warmly welcome everyone to attend the talk and the Soft Matter Coffee Break after the seminar, held in room 2.63 (2nd floor). Maria Ekiel-Je?ewska Maciej Lisicki Piotr Szymczak Panagiotis Theodorakis Marek Trippenbach ? -- Dr hab. Maciej Lisicki, prof. UW Institute of Theoretical Physics | Faculty of Physics University of Warsaw softmatter.fuw.edu.pl -------------- next part -------------- An HTML attachment was scrubbed... URL: -------------- next part -------------- A non-text attachment was scrubbed... Name: abstract.pdf Type: application/pdf Size: 1159752 bytes Desc: not available URL: -------------- next part -------------- An HTML attachment was scrubbed... URL: From Maciej.Lisicki at fuw.edu.pl Mon Oct 21 21:06:21 2024 From: Maciej.Lisicki at fuw.edu.pl (Maciej Lisicki) Date: Mon, 21 Oct 2024 21:06:21 +0200 Subject: [Soft-matter] Soft Matter & Complex Systems Seminar on 25 Oct 2024 Message-ID: Dear Soft Matter & Complex Systems Colleagues and Friends, On Friday 25 October 2024 at 9:30 AM at the UW Faculty of Physics (Pasteura 5, Warsaw; room 1.40) we are hosting a seminar during which ?ukasz Klotz (Warsaw University of Technology) will give a talk Influence of porous material on the flow behind backward-facing step - experimental study Abstract We investigate effect of porous insert located upstream of the separation edge of backward facing step (BFS) in early transitional regime as a function of Reynolds number. This is an example of hydrodynamic system that is a combination of separated shear flow with large amplification potential and porous materials known for efficient flow destabilisation. Spectral analysis reveals that dynamics of backward-facing step is dominated by spectral modes that remain globally coherent along the streamwise direction. We detect two branches of characteristic frequencies in the flow and with Hilbert transform we characterise their spatial support. For low Reynolds numbers, the dynamics of the flow is dominated by lower frequency, whereas for sufficiently large Reynolds numbers cross-over to higher frequencies is observed. Increasing permeability of the porous insert results in decrease in Reynolds number value, at which frequency cross-over occurs. By comparing normalized frequencies on each branch with local stability analysis, we attribute Kelvin-Helmholtz and Tollmien-Schlichting instabilities to upper and lower frequency branches, respectively. Finally, our results show that porous inserts enhance Kelvin-Helmholtz instability and promote transition to oscillator type dynamics. Specifically, the amplitude of vortical (BFS) structures associated with higher frequency branch follows Landau model prediction for all investigated porous inserts. We warmly welcome everyone to attend the talk and the Soft Matter Coffee Break after the seminar, held in room 2.63 (2nd floor). Maria Ekiel-Je?ewska Maciej Lisicki Piotr Szymczak Panagiotis Theodorakis Marek Trippenbach -------------- next part -------------- An HTML attachment was scrubbed... URL: From panos at ifpan.edu.pl Tue Oct 29 20:55:42 2024 From: panos at ifpan.edu.pl (Panagiotis Theodorakis) Date: Tue, 29 Oct 2024 20:55:42 +0100 Subject: [Soft-matter] Prof. David J. Wales - SPOTLIGHT TALK at 12:00 AM on October 30th In-Reply-To: <9901ece9484ac1d755872237e473cce0@ifpan.edu.pl> References: <9901ece9484ac1d755872237e473cce0@ifpan.edu.pl> Message-ID: <92860364ebf66f28b867a410baa86d1e@ifpan.edu.pl> Dear all, Prof. David Wales from University of Cambridge will give a spotlight talk at IP PAS at noon tomorrow, which will also be transmitted online. Please, see the attached for details and finding the Zoom link. Kind regards, Panos -------------- next part -------------- An HTML attachment was scrubbed... URL: -------------- next part -------------- A non-text attachment was scrubbed... Name: Spotlight-D.Wales.pdf Type: application/pdf Size: 209338 bytes Desc: not available URL: