[Soft-matter] Soft Matter & Complex Systems Seminar on 9 Jan 2026

[Maciej Lisicki]

Dear Soft Matter & Complex Systems Colleagues and Friends,

Happy New Year! On Friday 9 January 2026 at 9:30 AM at the UW Faculty of Physics (Pasteura 5, Warsaw; room 1.40) we are hosting a seminar, during which 

Tomasz Lipniacki (IPPT PAN)

will give a talk
Antagonism between viral infection and innate immunity at the single-cell level

Abstract

Authors: Frederic Grabowski, Marek Kochańczyk, Zbigniew Korwek, Maciej Czerkies, Wiktor Prus, Tomasz Lipniacki
(Institute of Fundamental Technological Research, Polish Academy of Sciences)

When infected with a virus, cells may secrete interferons (IFNs) that prompt nearby cells to prepare for upcoming infection. Reciprocally, viral proteins often interfere with IFN synthesis and IFN-induced signaling. We modeled the crosstalk between the propagating virus and the innate immune response using an agent-based stochastic approach. By analyzing immunofluorescence microscopy images we observed that the mutual antagonism between the respiratory syncytial virus (RSV) and infected A549 cells leads to dichotomous responses at the single-cell level and complex spatial patterns of cell signaling states. Our analysis indicates that RSV blocks innate responses at three levels: by inhibition of IRF3 activation, inhibition of IFN synthesis, and inhibition of STAT1/2 activation. In turn, proteins coded by IFN-stimulated (STAT1/2-activated) genes inhibit the synthesis of viral RNA and viral proteins. The striking consequence of these inhibitions is a lack of coincidence of viral proteins and IFN expression within single cells.

PloS Pathogens, 2023

We warmly welcome everyone to attend the talk and the Soft Matter Coffee Break after the seminar, held in room 2.63 (2nd floor).

Maria Ekiel-Jeżewska
Maciej Lisicki
Piotr Szymczak
Panagiotis Theodorakis

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