<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class="">Dear Soft Matter Colleagues and Friends,</span></div><div style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;" class=""><span style="font-kerning: none" class=""></span><br class=""></div><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class="">On Friday 16 October 2020 we will host a seminar during which</span></div><div style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;" class=""><span style="font-kerning: none" class=""></span><br class=""></div><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class=""><b class="">Tomasz Skóra</b> (IChF PAN)</span></div><div style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;" class=""><span style="font-kerning: none" class=""></span><br class=""></div><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class="">will give a talk</span></div><div style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;" class=""><span style="font-kerning: none" class=""></span><br class=""></div><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class=""><b class="">Macromolecular Crowding: How the Shape of Macromolecules Affects Diffusion?</b></span></div><div style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;" class=""><span style="font-kerning: none" class=""></span><br class=""></div><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class=""><b class="">Abstract</b></span></div><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class="">Significant fraction of cell’s volume is occupied by various proteins, polysaccharides, RNAs etc. Such crowding substantially reduces the mobility of macromolecules, and affects both thermodynamics and kinetics of intracellular processes. While prior research has mainly focused on the dependence of translational mobility on occupied volume fraction, studies of the effect of crowder shape are still scarce. In this work, we fill this gap by investigating self-diffusion in mixtures of spherical and elongated macromolecules with Fluorescence Correlation Spectroscopy (FCS) and Brownian Dynamics (BD) simulations. Our results emphasize that diffusion in crowded systems is determined not merely by the occupied volume fraction, but that the shape of crowders matters, which is relevant to diverse intracellular environments.</span></div><div style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;" class=""><span style="font-kerning: none" class=""></span><br class=""></div><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class="">The seminar will be conducted via Zoom</span></div><div style="margin: 0px; font-stretch: normal; line-height: normal; color: rgb(9, 79, 209);" class=""><span style="text-decoration: underline ; font-kerning: none" class=""><a href="https://zoom.us/j/92987083349?pwd=YTZLSFVWUnJzdE4xS1drR3dqMVFDdz09" class="">https://zoom.us/j/92987083349?pwd=YTZLSFVWUnJzdE4xS1drR3dqMVFDdz09</a></span></div><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class="">Meeting ID: 929 8708 3349</span></div><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class="">Passcode: a8QhyS</span></div><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class="">and will begin at <b class="">9:30AM</b>. </span></div><div style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;" class=""><span style="font-kerning: none" class=""></span><br class=""></div><div style="margin: 0px; text-align: justify; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class="">Everyone is very welcome to attend and ask questions over Zoom. A limited number of participants may be present in the seminar room. We would like to ask those interested in attending in person to contact the organisers prior to the seminar to ensure safety.</span></div><div style="margin: 0px; text-align: justify; font-stretch: normal; line-height: normal; min-height: 14px;" class=""><span style="font-kerning: none" class=""></span><br class=""></div><div style="margin: 0px; text-align: justify; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class="">Maria Ekiel-Jeżewska</span></div><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class="">Maciej Lisicki</span></div><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class="">Marek Napiórkowski</span></div><div style="margin: 0px; font-stretch: normal; line-height: normal;" class=""><span style="font-kerning: none" class="">Piotr Szymczak</span></div>
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