<html><head><meta http-equiv="content-type" content="text/html; charset=utf-8"></head><body style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div style="font-family: HelveticaNeue;"><font face="HelveticaNeue">Dear Soft Matter & Complex Systems Colleagues and Friends,</font></div><div style="font-family: HelveticaNeue;"><font face="HelveticaNeue"><br></font></div><div style="font-family: HelveticaNeue;"><div><font face="HelveticaNeue">On Friday 10 November 2023 at 9:30 AM at the UW Faculty of Physics (Pasteura 5, Warsaw; room 1.40) we are hosting a seminar during which</font></div><div style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><b><br></b></div><div style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><font face="HelveticaNeue"><b>Dorota Niedziałek </b>(</font>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw & Molecure S.A. Warsaw)</div><div style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><font face="HelveticaNeue"><br></font></div><div style="margin: 0px; font-stretch: normal; line-height: normal;"><font face="HelveticaNeue">will give a talk</font></div><div style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><span style="caret-color: rgb(68, 68, 68);"><br></span></div><div style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><span style="caret-color: rgb(68, 68, 68);"><b>The rocket science behind enzymatic machinery</b></span></div><div style="margin: 0px; font-stretch: normal; line-height: normal;"><div style="margin: 0px; font-stretch: normal; line-height: normal;"><div style="margin: 0px; font-stretch: normal; line-height: normal;"><h2 style="margin: 6px 0px 12px; padding: 0px; caret-color: rgb(68, 68, 68);"><b style="font-size: 12px;">Abstract</b></h2></div></div></div><div style="margin: 0px; font-stretch: normal; line-height: normal;"><div style="margin: 0px; font-stretch: normal; line-height: normal;"><div style="margin: 0px; font-stretch: normal; line-height: normal;"><div style="margin: 0px; font-stretch: normal; line-height: normal;"><div style="margin: 0px; font-stretch: normal; line-height: normal;">The understanding of the catalytic process of a targeted enzyme might be a very important step for successful drug design process. Having an experimentally resolved structure is a must. Yet, it is merely a starting point of the way towards understanding the full picture of the enzyme's mechanism of action. There are several levels of theory we can use for studying an enzymatic machinery. The classical models fail to properly describe catalytic reactions. I would like to show you how we can overcome that limitations by using a combination of polarizable force field models and quantum mechanical calculations.</div><div><br></div></div></div></div></div><div style="margin: 0px; font-stretch: normal; line-height: normal;"><font face="HelveticaNeue">We warmly welcome everyone to attend the talk and the Soft Matter Coffee Break after the seminar, held in room 2.63 (2nd floor).</font></div></div><div style="font-family: HelveticaNeue;"><font face="HelveticaNeue"><br></font></div><div style="font-family: HelveticaNeue;"><div dir="auto" style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div style="margin: 0px; font-stretch: normal; line-height: normal;"><font face="HelveticaNeue">Maria Ekiel-Jeżewska</font></div><div style="margin: 0px; font-stretch: normal; line-height: normal;"><font face="HelveticaNeue">Maciej Lisicki</font></div><div style="margin: 0px; font-stretch: normal; line-height: normal;"><font face="HelveticaNeue">Piotr Szymczak</font></div><div style="margin: 0px; font-stretch: normal; line-height: normal;"><font face="HelveticaNeue">Panagiotis Theodorakis</font></div><div style="margin: 0px; font-stretch: normal; line-height: normal;"><font face="HelveticaNeue">Marek Trippenbach</font></div></div></div><br><br></body></html>